Review Boards: Recombinant DNA

The IBC is responsible for reviewing all research involving recombinant DNA molecules conducted under the aegis of Michigan Technological University. Recombinant DNA molecules are defined as either (i) molecules that are constructed outside living cells by joining natural or synthetic DNA segments to DNA molecules that can replicate in a living cell, or (ii) DNA molecules that result from the replication of those described in (i).

All research involving recombinant DNA molecules must be registered with the University's Institutional Biosafety Committee (IBC). Some classes of recombinant DNA research are also subject to review and approval by the IBC.

I. REGULATIONS

Revised regulations were issued by the National Institutes of Health (NIH) in January 2001, titled Guidelines for Research Involving Recombinant DNA Molecules. The purpose is to specify practices for constructing and handling recombinant DNA molecules and organisms and viruses containing recombinant DNA molecules. Federal guidelines are available at http://www4.od.nih.gov/oba/rac/guidelines/guidelines.html

II. INSTITUTIONAL BIOSAFETY COMMITTEE (IBC)

The IBC currently has 5 members. The IBC meets once a year and reviews research by mail year-round. Information on the status of the IBC is submitted annually to the Office of Recombinant DNA Activities, NIH.

III. REGISTRATION/REVIEW OF RESEARCH BY THE IBC

It is anticipated that most research conducted at Michigan Tech University will fall into categories which are exempt from review according to the NIH guidelines. However, all recombinant DNA research must be registered with the IBC using the Registration Document for Recombinant DNA Research. This completed document and a one-page description of the experimental methodology and containment procedures needs be submitted to the Research Compliance office.